After you have downloaded the OS archive, decompress it, and then flash .img boot image to a minimum 8GB USB thumb drive.
Set access key and worker name in the config file on the thumb drive.
Boot the rig from the USB thumb drive. No monitor, keyboard or mouse is necessary - all subsequent administration can be done from the dashboard.
While you wait for boot to finish, you can set up your dashboard and add new worker(s).
Minerstat OS will automatically configure and optimize itself to mine with your AMD and/or NVIDIA cards.
All you need to setup are your workers, mining pools, and addresses to which you want to mine. You can do that through dashboard.